闵三弟; 臧珍娣; 宋士良; 劳华均; 严惠芳; 陆宏祺
上海市农业科学院食用菌研究所!上海201106; 上海市农业科学院食用菌研究所!上海201106; 上海市农业科学院食用菌研究所!上海201106; 上海市农业科学院食用菌研究所!上海201106; 上海医药工业研究院药理室!上海200437; 上海医药工业研究院药理室!上海200437
【中文摘要】 从灵芝子实体用热水提取分离的灵芝多糖（GLP）对Lewis肺癌和结肠癌具有相当高的抑制生长活性,并能增强正常小鼠腹腔巨噬细胞吞噬作用和荷瘤小鼠NK细胞活性,从而提高机体免疫功能.灵芝多糖口服给药剂量每天每公斤C57BL/6小鼠2000mg.足趾接种和腑皮下接种对Lewis肺癌的抑制率分别为53.54％～59.13 ％和36.43％～42.76％;对结肠癌的抑制率分别为42.47％～49.14％和29.43％～32.09％.
【英文摘要】 The polysaccharide of Ganoderma lucidum (GLP), isolated from hot-water extracts of Ganoderma lucidum fruitbody has relatively high growth-inhibition activities against Lewis lung carcinoma and colon cancer and enhances immune function of the mice which took it. GLP is taken orally by C57BL/6 mice at a dosage of 2000mg per day and the inhibition rate of Lewis lung carcinoma by subcutaneous inoculation to mice at toe and axillary is about 53.54 %-59.13 % and 36.43 %-42.76 % respectively. The inhibition rate of colon cancer by inoculation to mice at toe and axillary is about 42.47% -49.13% and 29.43-32.09% respectively. Meanwhile, GLP enhances the phagocytosis of macrophage in abdominal cavity of normal mice and activities of NK cells of tumor-bearing mice.
【中文关键词】 灵芝; 子实体; 多糖; 抗肿瘤活性
【英文关键词】 Ganoderma lucidum; Fruitbody; Polysaccharide; Antitumor activity
【文献出处】 食用菌学报,Acta Edulis Fungi,编辑部邮箱,1996年01期 【DOI】CNKI:SUN:SYJB.0.1996-01-003