【作者】 许胜杰； 林文川； 林定威； 陈劲初；
【Author】 SHEU Senje 1,LIN Wenchuan2,LIN Tingwei1,CHEN Cinchu1 1Grape King Enterprises Corp.,Shanghai 201611,China;2School of Medicine,China Medical University,Taichung,Taiwan 40402,China
【机构】 上海葡萄王企业有限公司； 中国医药大学医学系；
【摘要】 为探讨樟芝(Antrodia cinnamomea)发酵液冻干粉对CCl4诱发的大鼠慢性肝炎的作用,构建CCl4诱发的大鼠慢性肝炎模型,结果表明处理6周时樟芝发酵液冻干粉可明显降低血清谷草转氨酶(glutamicoxaloacetic transaminase,GOT)、谷丙转氨酶(glutamic pyruvic transaminase,GPT)的活性及白蛋白含量;第8周可增加血清白蛋白含量,明显减轻脾脏重量,增加肝脏蛋白质含量及降低肝脏含水量、脂质过氧化程度和羟脯氨酸含量。因此,樟芝发酵液冻干粉可以减轻CCl4所诱发的大鼠慢性肝炎症状。
【Abstract】 The protective effects of powdered freeze-dried fermentation broth(FDFB),prepared from submerged cultures of Antrodia cinnamomea,against carbon tetrachloride(CCl4)-induced chronic hepatitis in rats are described.Doses of 20% CCl4(0.2 mL/100 g body weight) were administered to rats twice weekly(every Wednesday and Saturday) for eight consecutive weeks.Each rat was orally administered FDFB daily until the end of the experiment and one day prior to CCl4 administration.A significant decrease in elev...
【关键词】 樟芝发酵液冻干粉； CCl4； 谷草转氨酶； 谷丙转氨酶；
【Key words】 Freeze-dried powder of Antrodia cinnamomea fermentation broth； carbon tetrachloride； glutamic oxaloacetic transaminase； glutamic pyruvic transaminase；
【分类号】S567.31