孙玉军; 陈彦; 周正义; 周丽伟
安徽科技学院生命科学学院; 安徽大学生命科学学院; 安徽科技学院生命科学学院; 安徽大学生命科学学院 安徽凤阳233100; 安徽合肥230039; 安徽凤阳233100; 安徽合肥230039
【中文摘要】 采用CCl4法进行肝损伤造模,测定小鼠血清谷丙转氨酶、谷草转氨酶和肝脏指数的变化,同时检测肝匀浆中超氧化物岐化酶(SOD)和丙二醛(MDA)含量。羊肚菌胞内多糖能明显降低血清中的谷丙转氨酶、谷草转氨酶活性,降低肝脏中MDA的含量和肝脏指数,提高SOD活性,并能显著地减轻CC14引起的肝小叶内的灶性坏死。结果表明羊肚菌胞内多糖对小鼠肝脏的损伤有保护作用。
【英文摘要】 To study the protective effects of intracellular polysaccharide from Morchella esculenta(MEP)on acute liver injury caused by CCl4 in mice,the mice were given i.g.MEP daily for 18 days before the models were made by i.p.injection of CCl4.The content of ALT,AST activity were measured in the serum,SOD,MDA were measured in the liver and 1iver index were also detected.MEP could significantly decrease the content of ALT,AST,MDA and liver index,and also improve SOD activity in liver.The lesions in liver lobule were ameliorated obviously.The results showed that MEP had protective effects on mice acute hepatic injury.
【中文关键词】 羊肚菌; 胞内多糖; 四氯化碳; 肝损伤
【英文关键词】 Acute liver injury; Morchella esculenta; Polysaccharide; Carbon tetrachloride
【基金】安徽省教育厅自然科学研究项目资助(No.2006KJ203B)
【文献出处】 中国食用菌,Edible Fungi of China,编辑部邮箱,2008年02期 【DOI】CNKI:SUN:ZSYJ.0.2008-02-017