【作者】 肖春； 吴清平； 蔡玟； 谭剑斌； 黄俊明； 杨小兵；
【Author】 XIAO Chun1,2,4,WU Qing-ping2,CAI Wen3,TAN Jian-bin3,HUANG Jun-ming3,YANG Xiao-bing2 (1.South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou Guangdong 510301;2.Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Institute of Microbiology,Guangzhou Guangdong 510070;3.Department of Toxicology of the Center for Disease Control and Prevention of Guangdong Province,Guangzhou Guangdong 510020;4.Graduate School of the Chinese Academy of Sciences,Beijing 100049)
【机构】 中国科学院南海海洋研究所； 广东省微生物研究所广东省菌种保藏与应用重点实验室； 中国科学院研究生院； 广东省疾病预防控制中心；
【摘要】 研究灵芝粗多糖对糖尿病小鼠的降血糖作用。灌胃5周后,剂量组与糖尿病模型对照组的血糖,有显著性差异(p<0.01),高剂量组与低剂量组的血糖水平,组间差异显著(p<0.01);剂量组小鼠的血清胰岛素值与糖尿病模型对照组比较,显著降低。灵芝粗多糖能显著降低糖尿病小鼠的空腹血糖,并呈现一定的剂量依赖关系,但其降血糖机理不是刺激胰岛素的分泌。
【Abstract】 The hypoglycemic effect of Ganoderma lucidum crude polysaccharides(GLP) in type 2 diabetes mellitus(DM) mice and hypoglycemic mechanism were investigated.The results showed that after five weeks,there existed a significant difference(p<0.01) in serum glucose between the test groups and the model control group,as well as between the high and the low-dose groups.However,GLP had no obvious effect on serum insulin.GLP was able to significantly decrease fasting blood glucose level in DM mice in ce...
【关键词】 灵芝粗多糖； 降血糖活性； 糖尿病；
【Key words】 Ganoderma lucidum crude polysaccharides； Hypoglycemic activity； Diabetes mellitus mice；
【基金】 广东省科技计划项目(项目编号:2008A020100024、2009GB2E000279)
【分类号】R285