【作者】 闫梅霞； 关一鸣； 胡清秀； 张瑞； 王英平； 杨元超；
【Author】 YAN Meixia1,2,GUAN Yiming2,HU Qingxiu1 ,ZHANG Rui2,WANG Yingping2,YANG Yuanchao21Institute of Agricultural Resources and Regional Planning,Chinese Academy of Agricultural Sciences,Beijing 100081,China;2Institute of Special Wild Economic Animal and Plant Science,Chinese Academy of Agricultural Sciences,Jilin,Jilin 132109,China
【机构】 中国农业科学院农业资源与农业区划研究所； 中国农业科学院特产研究所；
【摘要】 对硫磺菌(Laetiporus sulphureus)液体发酵菌丝粗多糖进行体内抗肿瘤研究,结果表明:硫磺菌粗多糖对Lewis肺癌的体内最大抑制作用为35.7%,粗多糖组对胸腺和脾脏的影响显著小于环磷酰胺。
【Abstract】 The antitumor activity of crude polysaccharide from Laetiporus sulphureus mycelium grown in submerged cultured was determined using Lewis lung cancer-bearing mice as the test model.Inhibitory effects on tumor growth were highest(35.7%) in mice administered 100 mg/mL of crude polysaccharide.However,spleen and thymus indices and animal weights were significant higher in polysaccharide-treated mice compared to positive control mice administered cyclophosphamide.
【关键词】 液体发酵； 粗多糖； 抗肿瘤；
【Key words】 Submerged culture； crude polysaccharide； antitumor activity；
【基金】 国家现代食用菌产业技术体系的岗位专家专项经费资助
【分类号】R734.2